Hereditary Central Nervous System Tumours
| Test Information | |
|---|---|
| Test Name | Hereditary Central Nervous System Tumours |
| Lab (Location) | University Health Network |
| Category | Cancer |
| Subcategory | Hereditary Central Nervous System (CNS) Tumours |
| Gene/Platform/Region List | APC, EPCAM, LZTR1, MLH1, MSH2, MSH6, NF1, NF2, PMS2, POLE, POT1, PTCH1, PTEN, SMARCB1, SMARCE1, SUFU, TP53, TSC1, TSC2, VHL |
| Test type | Gene Panel |
| Samples Accepted | Blood, DNA, Saliva |
| Indications Diagnosis | Diagnosis, Carrier / Cascade Testing |
| Test Methodology | CNV, Sequencing |
| Methodology Notes | EPCAM CNV only |
| Diseases/Conditions | Central Nervous System Gene Panel, Neurofibromatosis type 1, Schwannomatosis, Familial adenomatous polyposis, Lynch Syndrome Panel, Von Hippel-Lindau Syndrome |
| Notes | Saliva samples must be provided in oragene, OG-600 kits; UHN does not provide collection kits but they can be obtained directly from DNA genotek (www.dnagenotek.com) |