12006

GDT Ontario Health Testing Eligibility HCT v3 GTD Indications Diagnosis Carrier / Cascade Testing GTD Samples Accepted Blood DNA Saliva GTD Test Methodology CNV Sequencing GTD Methodology Notes EPCAM and GREM1 CNV only GTD Notes Saliva samples must be provided in oragene, OG-600 kits; UHN does not provide collection kits but they can be obtained directly from DNA genotek (www.dnagenotek.com) Generic Test name (cms title) Hereditary Comprehensive Cancer GTD Test type Gene Panel GTD Location University Health Network GTD Gene/Platform/Region List AIP, APC, ATM, AXIN2, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDC73, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2, CTNNA1, DICER1, EGFR (T790M, V834I, V769M), EGLN1, EPCAM, EXT1, EXT2, FH, FLCN, GALNT12, GREM1, HOXB13 (G84E), KIT, LZTR1, MAX, MEN1, MET, MITF (E318K), MLH1, MLH3, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NF2, NTHL1, PALB2, PDGFRA, PMS2, POLD1, POLE, POT1, PRKAR1A, PTCH1, PTEN, RAD51C, RAD51D, RB1, RECQL, RET, RNF43, RPS20, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SMARCB1, SMARCE1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL GTD Category Cancer GTD Disease/Condition Comprehensive Cancer Panel (76 genes)